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27-09-2014, 08:26 PM
سعد الدين
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Chemistry of Bioconjugates: Synthesis, Characterization, and Biomedical Applications

Chemistry of Bioconjugates: Synthesis, Characterization, and Biomedical Applications

PREFACE
Combining characteristics of different components into one
to generate new molecular systems with unique properties by
simply linking one or more (macro)molecules is defined as
bioconjugation. The ability to create such biohybrids either
covalently or non-covalently has allowed major breakthrough
in many industrial and biomedical areas such as bioseparation,
targeting, detection, biosensing, biological assays,
etc. This book provides a comprehensive account on the
chemistries involved in the formation of bioconjugates, followed
by an extensive review of all the different types of
bioconjugates generated so far from polymers, dendrimers,
nanoparticles, carbon nanotubes, hydrogels and so on for
different bio-related applications. A section is also devoted
to the physicochemical and biochemical properties of bioconjugates.
Finally, the book also provides a comprehensive
account on the significance of bioconjugation which is lacking
in many of the current available resources.
The book begins by providing an overview of the chemistry
involved in bioconjugation. Different types of bioconjugation
strategies available for the modification of
biomolecules (proteins, peptides, carbohydrates, polymers,
DNA) are presented. Classical bioconjugation approaches
are described first, followed by some recent bioconjugation
techniques. This section also provides detailed synthetic protocols
for some of the most important strategies for bioconjugation.

Polymer bioconjugates are then discussed separately in
three sections, namely polyethylene glycol (PEG), synthetic
polymer bioconjugates, and natural polymer bioconjugates.
PEG has been extensively used in the development of
macromolecular therapeutics and most of the current clinically
available therapeutics are PEGylated bioconjugates.
PEGylation has been used for proteins, anticancer drugs,
and other bioactive molecules such as peptides, antibodies,
oligonucleotides, aptamers, red blood cells, and more
recently, viruses. Conjugation of synthetic polymers to
biomolecules is an appealing strategy to produce new
biomacromolecules with distinctive properties. Typical
conjugation strategies are either “grafting from” or “grafting
to” approaches. In “grafting from” approach, monomerfunctionalized
biomolecules are polymerized to produce
synthetic polymer bioconjugates. On the other hand, in
“grafting to” approach, biomolecules are immobilized
by reactive coupling reactions. Random and site-specific
modifications of natural macromolecules have also been
extensively studied and, therefore, an elaborated section has
been devoted to this area.

The next section is focused on organic nanoparticle
bioconjugates. Different chemical strategies used to couple
biomolecules with liposomes, micelles, carbon nanotubes,
fullerene, and graphene are discussed. Bioconjugation
of biomolecules to those organic nanoparticles has
become increasingly important in drug formulation and therapeutic
delivery. Choosing the right chemistry between the
biomolecule and organic nanoparticle has been the focus of
great attention in recent years in view of improving the sustained
delivery of these bioconjugates to the targeted site
effectively. Carbon nanotubes, fullerene, and graphene have
unique properties and their coupling with biomolecules have
generated unique materials of high potency in biomedical
applications.

Explores bioconjugate properties and applications of polymers, dendrimers, lipids, nanoparticles, and nanotubes

Bioconjugation has enabled breakthroughs across many areas of industry and biomedicine.

With its emphasis on synthesis, properties and applications, this book enables readers to
understand the connection between chemistry and the biological application of bioconjugated materials.


2014 -- ISBN-10: 1118359143 -- 496 pages -- PDF -- 18 MB

Download
http://damasgate.com/vb/members-area/s18/srvs2/02/003...plications.rar




27-09-2014, 10:27 PM
محـــمد ظافـــر
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جزاك الله خيرا اخي العزيز

27-09-2014, 11:41 PM
ربيع
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بارك الله فيك وجزاك خيراً أخي العزيز

05-10-2016, 10:47 AM
wissamrzaidan
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شكرا لكم
جزاكم الله ما تستحقون
وانعم عليكم بما تتمنون من الخير لاهل الخير

24-10-2017, 02:05 PM
giverdi
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Thanks


Chemistry of Bioconjugates: Synthesis, Characterization, and Biomedical Applications



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